發布於 2018-10-10
觀看次數: 25
  • 00:34 1.
    index 1
  • 05:12 2.
    KEY CONCEPTS: Section 4-3
  • 02:25 3.
    A folded polypeptide assumes a shape with a hydrophilic surface and a hydrophobic core.
  • 04:23 4.
    Protein folding and protein stabilization depend on noncovalent forces.
  • 01:00 5.
    KEY CONCEPTS: Section 4-4
  • 04:59 6.
    Domains vs. Subunits
  • 05:52 7.
    KEY CONCEPTS: Section 4-5
  • 02:58 8.
    Chromatography is a technique for separating molecules on the basis of size, charge, or specific binding.
  • 03:24 9.
    Gel Filtration Chromatography
  • 02:48 10.
    Ion Exchange Chromatography
  • 02:34 11.
    Crystals of the ProteinStreptavidin
  • 02:26 12.
    The NMR Structure ofGlutaredoxin
  • 00:11 13.
    ** after ch04 Protein structure(106-2-16).ppt
  • 00:03 14.
    index 2
  • 05:03 15.
    Proteins serve a variety of functions.
  • 02:07 16.
    Proteins serve a variety of functions.
  • 03:55 17.
    KEY CONCEPTS: Section 5-1
  • 03:19 18.
    Why focus on myoglobin and hemoglobin?
  • 02:59 19.
    Myoglobin is a classical globular protein.
  • 04:15 20.
    Heme is a prosthetic group.
  • 04:31 21.
    Myoglobin transports O2 via the Fe in heme.
  • 02:03 22.
    How can binding of O2 to myoglobin be described?
  • 05:59 23.
    Myoglobin binds to O2 in a hyperbolic trend.
  • 01:43 24.
    O2 binds to the heme group of myoglobin such that binding is half-maximal when the oxygen concentration is equal to the dissociation constant.
  • 01:16 25.
    Remember!
  • 03:32 26.
    Mb and Hb are only ~18% identical in primary sequence.
  • 01:34 27.
    Mb and Hb are similar in their secondary and tertiary structures.
  • 02:01 28.
    The similarities in structure and sequence between myoglobin and hemoglobin indicate a common evolutionary origin.
  • 01:11 29.
    How to Express Affinity in Biochemistry?
  • 00:30 30.
    Collagen is a triple helix.
  • 01:50 31.
    Collagen is covalently cross-linked.
  • 01:26 32.
    Collagen has a noteworthy sequence.
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1:28:21, 發布於 2018-10-10 by 梅書瑄